Priority Research Area Asthma and Allergy
Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev. Clinical characteristics of illness caused by Bordetella parapertussis compared with illness caused by Bordetella pertussis. Pediatr Infect Dis J. Recovery of Bordetella holmesii from patients with pertussis-like symptoms: use of pulsed-field gel electrophoresis to characterize circulating strains.
J Clin Microbiol. PubMed Abstract Google Scholar. An update of the global burden of pertussis in children younger than 5 years: a modelling study. Lancet Infect Dis. Global routine vaccination coverage, Black S. Epidemiology of pertussis. Pertussis of adults and infants. Pertussis resurgence: perspectives from the Working Group Meeting on pertussis on the causes, possible paths forward, and gaps in our knowledge.
J Infect Dis. Prevalence of asymptomatic Bordetella pertussis and Bordetella parapertussis infections among school children in China as determined by pooled real-time PCR: a cross-sectional study. Scand J Infect Dis. Seroprevalence of pertussis in The Netherlands: evidence for increased circulation of Bordetella pertussis. Antibody responses to Bordetella pertussis antigens and clinical correlations in elderly community residents.
Clin Infect Dis. A high seroprevalence of antibodies to pertussis toxin among Japanese adults: qualitative and quantitative analyses. Seroprevalence of pertussis in the Gambia: evidence for continued circulation of Bordetella pertussis despite high vaccination rates. Asymptomatic transmission and the resurgence of Bordetella pertussis. BMC Med. Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model. Unexpected isolation of Bordetella pertussis from a blood culture. J Exp Med. Immunity to the respiratory pathogen Bordetella pertussis.
Mucosal Immunol. Bordetella pertussis infection induces a mucosal IL response and long-lived Th17 and Th1 immune memory cells in nonhuman primates. Cutting edge: lung mucosal Thmediated responses induce polymeric Ig receptor expression by the airway epithelium and elevate secretory IgA levels.
J Immunol. Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses. Enzyme-linked immunosorbent assay for detection of pertussis immunoglobulin A in nasopharyngeal secretions as an indicator of recent infection.
Immunity against mucosal pathogens.
Characterization of antibody inhibiting adherence of Bordetella pertussis to human respiratory epithelial cells. Immunoglobulin A-mediated protection against Bordetella pertussis infection. Infect Immun. Comparative role of immunoglobulin A in protective immunity against the Bordetellae. Live attenuated B. PLoS Pathog. Compartmentalization of T cell responses following respiratory infection with Bordetella pertussis : hyporesponsiveness of lung T cells is associated with modulated expression of the co-stimulatory molecule CD Eur J Immunol.
Andreasen C, Carbonetti NH. Role of neutrophils in response to Bordetella pertussis infection in mice. Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis. J Clin Invest. Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract. Cell-mediated immunity to Bordetella pertussis : role of Th1 cells in bacterial clearance in a murine respiratory infection model. Inflammasome activation by adenlyate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.
Role of gamma interferon in natural clearance of Bordetella pertussis infection. Lung CD4 tissue-resident memory T cells mediate adaptive immunity induced by previous infection of mice with Bordetella pertussis. Lung niches for the generation and maintenance of tissue-resident memory T cells. ILProducing innate and pathogen-specific tissue resident memory gammadelta T cells expand in the lungs of Bordetella pertussis -infected mice.
Wearing HJ, Rohani P. Estimating the duration of pertussis immunity using epidemiological signatures. Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces ILsecreting T RM cells. Molecular signatures of the evolving immune response in mice following a Bordetella pertussis infection.
Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion or protective T helper type 1 responses by Bordetella pertussis. Toll-like receptor 4-mediated innate IL activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. Oral immunization of newborn infants against pertussis. Monat Kinder.
ID Not Found. Preliminary findings with oral whooping cough vaccination in young infants. Wien Klin Wochenschr. Development and clinical use of an oral heat-inactivated whole cell pertussis vaccine. Dev Biol Stand. Characterization of a Salmonella typhimurmium aro vaccine strain expressing the P. Murine antibody response to oral infection with live aroA recombinant Salmonella dublin vaccine strains expressing filamentous hemagglutinin antigen from Bordetella petussis.
Antibody responses in the lungs of mice following oral immunization with Salmonella typhimurium aroA and invasive Escherichia coli strains expressing the filamentous hemagglutinin of Bordetella pertussis. Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections.
The ins and outs of pertussis toxin. FEBS J. Specific lung mucosal and systemic immune responses of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit. Construction and characterization of Salmonella typhimurium aroA simultaneously expressing the five pertussis toxin subunts.
Vaccine —9. Oral colonization and immune responses to Streptococcus gordonii expressing a pertussis toxin S1 fragment in mice. Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1and Th2 cells. Vaccine — Dow RP. Active immunisation by the intranasal route.
Can J Publ Health Google Scholar. North EA, Anderson G. Active immunisation by the intranasal route in experimental pertussis. Med J Aust. Cooper GN. Active immunity in mice following the intranasal injection of sub-lethal doses of living Haemophilus pertussis. J Pathol Bacteriol. Shapiro-Shapin CG. Pearl Kendrick, Grace Eldering, and the pertussis vaccine. Emerg Infect Dis. Thomas G. Respiratory and humoral immune response to aerosol and intramuscular pertussis vaccine.
J Hyg Camb. A nasal whole-cell pertussis vaccine induces specific systemic and cross-reactive mucosal antibody responses in human volunteers. J Med Microbiol.
Induction of antigen-specific T cell responses in human volunteers after intranasal immunization with a whole-cell pertussis vaccine. Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein. Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells.
A nasal whole-cell pertussis vaccine can induce strong systemic and mucosal antibody responses which are not enhanced by cholera toxin. Vaccine —8.